I'm running Mac OS 12, Lightroom 6.8 (just upgraded from 6.7), Epson XP-820 printer.
Recently I have been unable to view the list of printer profiles either in the Print or Develop modules when softproofing . Display profiles are listed. Older photos softproofed and printed in the past still have the reference to XP 820 720 620 520 Series Ultra Glossy.icc, Relative, but if I change to a display profile the printer profile disappears forever, and I am unable to retrieve it. Where is that profile list stored? Can I view it in a library somewhere. Updates have not restored that list, maybe even made it disappear. I'm even wondering if softproofing is functioning as it should. Choosing Perceptual, Relative, or Simulate Paper and Ink don't make any apparent changes. Any thoughts would be appreciated.
I'd be very surprised if the Epson XP-820 printer uses CMYK profiles.
With very few exceptions, desktop printers which do not use RIP software do not use CMYK profiles.
I downloaded an ICC profile for that Epson machine and as I expected its "RGB" so this is not a matter of Lightroom removing CMYK profile support.
So: try this-
Epson printer profiles are missing in Photoshop manages color* in the print dialog
*whilst my explnation here seems to specifically deal with a Photoshop issue it also applies to any Adobe application's inability to "see" Epson profiles
To use "Photoshop Manages Color" properly (to make accurate prints) you need access to the printer manufacturer's paper specific profiles, since you need to select the relevant paper profile in that dialog.
Using "Printer Manages Color" should work for Epson’s own papers, as long as the printer driver is correctly installed.
Printer Manages Color [based on the media type selected] calls upon ICC printer profiles from a different installed folder*
[*usually a hidden one, this is so they don't get deleted inadvertently, more on that and how to find them below].
Epson ICC printer profiles may be missing in Photoshop after updating macOSX. This issue started with Mojave.