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When I click the spot removal simbol the foto being processed became negative
The first thing that you should try is to switch off the GPU support from the Lightroom preferences and check if that helps to fix the issue.
Go to Lightroom > Preferences > Performance tab > Uncheck "Use Graphics Processor" > Restart Lightroom.
Another step is to try to reset the Lightroom preferences.
If this doesn't help we need more informations about your environment.
Which operating system do you use?
Which version of Lightroom do you use?
Please post the exact version and not only phrases as "recent", "latest" and so on.