I'm a real estate photographer and my family team edits about 100 photos each day.. During our editing process we apply perspective corrections so in post-edit to make additional adjustments we frequently use luminence masking using one of our exposures. Before we apply the mask we have to align layers. About 1 in 10 times we have to manually shift the aligned layer over by 5 pixels. It's not always the same direction, usually left or right but occasionally up or down. It seems like a bug in the fact that it occurs so commonly and at 5-7 pixels distance every single time. It also seems like a bug because I can manually fix it by simply using the arrow keys to move the layer over aligning the entire image perfectly. This happens regardless the resolution, or camera / drone shots we bracket. This has been happening since I converted to using Photoshop for everything we do about 2 years ago.
Across 6 different computer setups we've used this occurs. So system information isn't relevant. Version of PS is not relevant as it's occured over every update the past 2 years we've been using PS.