Attached is the screen I get upon opening Photoshop directly from the desktop. (latest version 22.4.2). It opens fine with an image via Bridge. The dialog box is what I get trying to creat a new image via File/New, opening an existing image via File/Open works. When I close any image, I am back to the blank gray screen. Windows 10, I've unchecked & rechecked the Graphics Processor tab in Preferences/Performance to no avail.
We're sorry about the trouble with Photoshop 22.4.2. Have you tried signing out of the Creative Cloud desktop app & signing back in or re-install Photoshop to check if that helps? If not, please try both the options to check how it goes.
You can also try to reset the preferences of Photoshop manually using the steps mentioned here: https://adobe.ly/2Qzc0K3