Brush moves autonomously just by clicking

[Stefano Marsi]

When I open an image through LR in PS (edit in PS2022) and I try to use the brush on it,
A simple click on the mouse moves the brush in NW direction even if I do NOT move the mouse !
Please note that the problem is present only on the principal screen (not on the secondary)
Moreover the problem is not present if the image is open directly using PS (and not through LR).

Video included.

[J453 · Accepted solution]

I think you might be hitting an issue related to this setting: 

https://helpx.adobe.com/photoshop/kb/high-dpi-scaling.html