After using camera raw (in photoshop or bridge) for a while (10~60 min), it will freeze suddenly. In this state, the image no longer changes with the edit, and the Cancel, Finish and Open buttons will be no response when clicking. An exclamation point can be found below.
In this state, I can only kill the photoshop or bridge process and lose all the changes.
Try resetting your ACR preferences, better? Hold down the Command key and select Photoshop > Preferences > Camera Raw (MacOS) or hold down the Ctrl key and select Edit > Preferences > Camera Raw (Windows). Click Yes in the dialog that asks "Delete the Camera Raw Preferences?"
Author “Color Management for Photographers" & "Photoshop CC Color Management/pluralsight"