I've have facing this problem for sometime now. If I have several images open at the same time in PS, one of the images goes to state where it doesn't close / save / anything.
If I hit ESC "save popup window flashes nano second" and I can go to another images and they work fine, but this one image gets stuck. If I hit X on image tab I just get error sound. All the menus are disabled too. Close All doesn't work either.
Only way to "solve" this is to do Force Quit and start over.