Layer-destructing bug affecting large files

[sboterod.]

. Photoshop 22.5.7

. Mac OS Catalina 10.15.7

. Since a couple of years ago, I have been getting this obnoxious bug in which layers are irreversibly destroyed in weird squared patterns. I have noticed that it likely happens with large files, but not close to the 2GB .psd size limit. 

. I would like to know how to deal with this problem, whether it is common or not, and what actions will Adobe take to fix it.

[Daniel Presedo]

There have been issues with Mac OS Catalina 10.15.7 and GPU support. 
If it is possible to try on another partiton or disk, I would consider working in Mac OS 11 or 12.  It may resolve those on screen issues.

[Jeff Arola]

See if going to Photoshop>Preferences>Technology Previews, checking/unchecking Disable Native Canvas and restarting photoshop makes any difference.

That is if Deactivate Native Canvas is already checked, uncheck it and vice versa.