Would you mind sharing your system specification and Photoshop version? Did you do any other troubleshooting steps apart from selecting "Deactivate Native Canvas"?
Your GPU should be enabled, check once if "Use Graphics Processor" (Performance > Preferences)is checked or not. Try resetting your Photoshop preferences defaults and check if that helps. Here's the article for the steps: https://adobe.ly/3ceal5t Also, back up the existing Photoshoppreferences if you have any custom brushes, action, and workspace: https://adobe.ly/2vNz6FG Close and re-launch Photoshop. Let us know if that helps.