Latest version of Photoshop doesn't save files exported from Lightroom if there was created one edit before.
Steps to reproduce this problem:
1. Ctrl + E to open RAW in Photoshop
2. Save file in Photoshop
3. Do again Ctrl + E on RAW in Lightroom
4. Now when trying to save second file, Photoshop does nothing. Even "Save as" doesn't work.