Photoshop CS6 - Blending options won't work on 8 bit files (only 16)

[Paul23517132yykk]

Not sure what is going on here and don't hold out a lot of hope for a solution as I have scoured the web and the problem is so weird. I am using Photoshop CS6 and out of the blue I cannot get blending options to work on any layers in my files, UNLESS I convert the file from 8 bit to 16 bit. Doesn't matter if it is a new file or an old one that I was previously working on successfully in 8 bit. Doesn't matter the file type or colorspace. Mode is always RGB. 

[Nancy OShea · Accepted solution]

When Photoshop behaves abnormally, Reset Preferences.

• Close Photoshop.
• Hold down Shift-Ctrl-Alt (PC) or Shift-cmd-option (Mac) and click the Photoshop icon (or double click if necessary) to start the application. Keep holding the 3 keys down.
• You will be asked to confirm that you wish to delete the Settings File: release the 3 keys and click on Yes.

Hope that helps.

[Paul23517132yykk]

Thank you! That did the job.