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I am using Photoshop on a MacBook Pro 2015 with the lastest version on Monterey. Yesterday, everything was working fine. Today, I open a file and the menu drop downs aren't functioning properly, most items are grayed out, and after a moment they stop working all together. I can't even close the window. Ultimately, I have to force quit. I've uninstalled, reinstalled. Restarted. Tried insalling an older version of PS. Thrown away preferences. Zapped PRAM. The same thing happened with InDesign, but I was able to fix it by throwing out my preferernces, but not so with PS.
Sorry to hear this @Frecklesoup23, you say you deleted your preferences, but did you do it manualy?
Let's make sure we're in a default state and there are no stale settings somewhere:
Restore your preferences using this manual method:
https://helpx.adobe.com/photoshop/using/preferences.html#Manually 
Does it work correctly?
If that doesn't solve it, you can quit Photoshop and put the Settings folder back.
It may help if we could see your Photoshop System Info. Launch Photoshop, and s
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Sorry to hear this @Frecklesoup23, you say you deleted your preferences, but did you do it manualy?
Let's make sure we're in a default state and there are no stale settings somewhere:
Restore your preferences using this manual method:
https://helpx.adobe.com/photoshop/using/preferences.html#Manually 
Does it work correctly?
If that doesn't solve it, you can quit Photoshop and put the Settings folder back.
It may help if we could see your Photoshop System Info. Launch Photoshop, and select Help >System Info...and copy/paste the text in a reply.
Thank you,
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@CoryShubert I did more digging over the weekend and saw references to this method of deleting preferences, and it DID work! I appreciate your reply—Thanks!