When I'm working on an illustration, sometimes my canvas will completely blank out. Although I can access everything from layers, to filters, to the navigation, the canvas can't be restored unless I close and relaunch the program. Resizing Photoshop, minimizing, tabbing out, waiting, etc, do nothing.
This has been going on for years and has gotten exponentially worse as of late. I save regularly, but it's become a frequent occurance, happening multiple times a day. If I'm lucky, I can salvage the illustration, but if I happen to be working with the pen tool then all my paths are lost and I have to start over.
I'm not sure if this is meaningful at all (my husband has all the computer-smarts, I just draw pictures) but my task manager says Photoshop is going bonkers.
Find out what kind of graphics card you have (GPU) and install new drivers from the company's website that makes your card; sometimes the graphics drivers stop reacting as expected for Photoshop and issues like this occur.