I have 2 machines, and both of them have serious issues with PS 22 that persist even after reinstalling.
On my Win 10 PC, Photoshop 22.4.2 opens just fine, but it completely refuses to open any file or create a new one. The program doesn't crash or freeze, but nothing at all happens whenever I try to create a file. Tool shortcuts still work and I can click on menu items, but I also can't open any file at all, whether through click & drag or through the open function.
On my Macbook Pro, (I can't remember the version number right now, but it's PS 22) I can't save my files unless I turn off all my layers. The zooming function is also buggy, every time I zoom in or out, the preview is stretched either horizontally or vertically, it's unpredictable.
PS 21 still works perfectly fine on both machines, so I could always revert back. But I think these issues are worth mentioning.