I started having this problem awhile ago. I thought maybe it was due to not having enough storage, but I deleted a ton of stuff off my computer and have over 100GB of free storage and it's still not working. I'll work on a file with layers and then Photoshop just stops responding and won't let me continue to edit. When I go to save, I get "Photoshop cannot save due to program error". I've read a lot of the forum questions and no one seems to be having this same problem. I see a lot of you aren't able to save your file, but I can't even edit mine. It's a fairly simple file, too. I've been using photoshop for 15 years and I've never had this happen.