We're sorry about the trouble with the Pen pressure in Photoshop 21.2.2. Please try enabling the option for Windows Ink in the Wacom drivers & removing the PSUserconfig file if you have created that in the settings for Photoshop.
If you have been following this topic as I have since I reported the issues you will notice that every user of Wacom reports problems with Windows Ink. >From all the messages and reports this fix does not work because Windows Ink is unusable. I can not update until we as Wacome user can still disable Windows Ink.