Photoshop 22.1 program errors (saving and healing brush)

[Ineedafingscreenname]

Recently (since the last update to 22.1), I've been regularly receiving program errors while using Photoshop.

Most worrisome is the program error I just received while trying to save a file. I have not figured out a work around yet. There is nothing unusual about the file. It resemembles many other files I've worked on earlier today and in the last week, all of which have saved without problems.

More commonly though, I receive a program error when I am using the healing brush. It will work maybe 20 times and then, for some unknown reason, it will not work on a single are of the image. I can continue to use the brush on other parts of the image (even some very close by that have the same texture, such as clear blue sky), but it consistently won't in that one spot of the image. To solve the problem, I just switch over to the clone tool instead. It has been a regular pain, but not the end of the world.

Whatever is going on, I've not seen these problems in Photoshop before and I'm especially worried about losing an hour or so of work. I may try to solve the problem by leaving Photoshop open for another hour, hoping it will auto-save, and then force quit the program so Auto Recover will come up next time.

In any case, any ideas?  I want to avoid all these problems in the future. I tried disabling the GPU for processing, but that did not work.

For reference, I'm using a Windows 10 Pro system. Lenovo laptop with a Intel HD Graphics P530 card. My system regularly updates on it's own, and Photoshop is fully updated.

[Ineedafingscreenname]

Also, apparently, I cannot flatten this same image...

[Ineedafingscreenname]

Interesting development: I deleted a single layer from my file (named "Layer 7" in the above image, which is a pixel layer I'm using to multiply dark areas) and the file saves just fine now.  I'm not sure what about that layer is so problematic; I've used the technique hundreds of times. But that seems to resolve the Save issue after trying many different other things.

[Ineedafingscreenname]

And here are the last error log, if it's helpful:

2021:01:05 13:39:45 : : 134 : REQUIRE failed
2021:01:05 13:39:45 : Stack : : 0 address: 0x00007FF75A4AD5F6 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
1 address: 0x00007FF758F93277 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
2 address: 0x00007FF758F92D82 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
3 address: 0x00007FF757410EAD base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
4 address: 0x00007FF757400DDC base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
5 address: 0x00007FF9FDFA6E2D base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
6 address: 0x00007FF9FDFA5961 base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
7 address: 0x00007FF9FDFAA51A base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
8 address: 0x00007FF9FDFAA600 base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
9 address: 0x00007FFA0A285D50 base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
10 address: 0x00007FFA0A2816EB base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
11 address: 0x00007FFA0A2818FE base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
12 address: 0x00007FFA0BC5FAC5 base: 0x00007FFA0BC20000 module name: 'SCCore.dll'
13 address: 0x00007FFA0A2882B3 base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
14 address: 0x00007FFA0A28375B base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
15 address: 0x00007FFA0A2816FD base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
16 address: 0x00007FFA0A293722 base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
17 address: 0x00007FFA0A2818FE base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
18 address: 0x00007FFA0A28A192 base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
19 address: 0x00007FFA0A2BC634 base: 0x00007FFA0A260000 module name: 'ExtendScript.dll'
20 address: 0x00007FF9FDFB9FD9 base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
21 address: 0x00007FF9FDFBA54D base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
22 address: 0x00007FF9FDFC0366 base: 0x00007FF9FDF10000 module name: 'ScriptingSupport.8li'
23 address: 0x00007FF7572D19F4 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
24 address: 0x00007FF7572FE006 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
25 address: 0x00007FF756F843D2 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
26 address: 0x00007FF756F784BE base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
27 address: 0x00007FF758F947F5 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
28 address: 0x00007FF756F7D384 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
29 address: 0x00007FF756D0E3D3 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
30 address: 0x00007FF756D0BBCD base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
31 address: 0x00007FF756D129E1 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
32 address: 0x00007FF756F9815F base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
33 address: 0x00007FF756D0051B base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
34 address: 0x00007FF756F5CB52 base: 0x00007FF7500A0000 module name: 'Photoshop.exe'
35 address: 0x00007FFA90277034 base: 0x00007FFA90260000 module name: 'KERNEL32.DLL'
36 address: 0x00007FFA9105D0D1 base: 0x00007FFA91010000 module name: 'ntdll.dll'

[PDmitry]

I have same 100% error log. But I have a problem, that after using any 3th part plugin   GPU support is turning off until I close images working on. It became after 22.1 version ((