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I have the annual subscription to Photoshop. Old version was the 2018 edition. Recently upgraded to the 2021. Can I uninstall 2018 from my desktop, or is the 2021 built upon it?
You can uninstall the earlier version(s) using the drop-down menu in the Creative Cloud app, there's no problem.
It's usually wise though to keep the previous version so you can access it if there are issues with the new version and maybe things like plugins may not have been updated yet.