Not automatically. The jpeg file format specification is extremely limited and supports basically nothing at all. Almost anything you can do to a file in Photoshop excludes jpeg as a direct option.
To save as jpeg, you need to save as a copy with the "offending" properties removed. That means you still have the original, complete file open, and you always need to decide what to do with that after the copy is saved out.
The only file formats that support all Photoshop functions are PSD and TIFF.