I’m unable to work with photoshop 22.x on iMac 2017 with Big Sur.
The program starts but no tasks can be performed. The spining wheel is almost constantly on screen.
It seems to take up all the memory of the system and the whole system really stops responding. Sometimes some error messages appear concerning the graphics card to the system out of memory. It is not even possible to close the program. A message appears that the program will close after the preset synchronization but it never ends. It is always necessary to perform a forced exit but often I cannot even call the forced exit panel of the system applications and then I have to shut down the Mac forcibly because the system does not respond either. Other times the Mac crashes and restarts by itself.
I have already sent the Mac for service and Apple is ruling out that there is a hardware problem.
I have not encountered any problems with Photoshop 21.2.6 and with the latest versions of Indesign and Illustrator.
You can adjust amount of memory available to Photoshop in Settings. I used to have same year Imac before and it worked fine. Memory limitation on Imac is irritating though, you can add so much more memory on PC systems... I had issues with large files from time to time, frustrating. Oh well.