Yep, have also been experiencing issues with lumetri colour where it will no longer update live. It's pretty bad on 25.0 on large timelines as well
Here is a screen recording of 25.0 on a rather large timeline, note; I am moving the mouse the entire time but it does not update until I let go. This is all footage proxied to prores - Moving to a smaller timeline does NOT change this behaviour for me. It happens regardless