I'll start off by saying I'm not sure whether this behaviour is intended due to the nature of the effect.
When applying Auto Reframe to a Source Clip, the other Sequences which include instances of said clip do not automatically adjust to their respective size/dimensions. In fact, the reframe only seems to happen to the newest Sequence that I created. Normal?
To reproduce, have two sequences at different sizes, drag the same clip onto both timelines then apply the Auto Reframe effect to the Source clip