Some eyedroppers do not work properly when color management is enabled.

[TaranVH]

If you enable the check box in Preferences > General > Display color management, it will adjust the colors on the Source and Program monitors according to that monitor’s associated .icm file. However, this is only for viewing purposes on that specific monitor.
For an eyedropper to work properly, it must sample the color as it exists BEFORE color management is applied to it. But most of the eyedroppers inside of Premiere will only sample a color AFTER it has been adjusted by color management.
You can prove this by turning on color management, then trying to use a Color Matte’s color picker to match something else with solid colors. The results will always be different. (As shown in the image with the color bars.)
Currently, the only way to properly sample any color is to turn off color management first, as I demonstrate in this short clip. (45:41 to 46:21)
https://youtu.be/QPubgoqtfbk?t=2741

Currently, only the eyedroppers inside the Lumetri Color effect work correctly when color management is enabled. (As far as I know)

[TaranVH]

Okay, people are telling me they're COLOR PICKERS, not "eye droppers." Yeah. That's probably a better name for them.

[Will5FF7]

It would be great to have this fixed, not cool to have to change color management every time I want to eye drop a color.

[Baffy19]

I support the author of the post and everyone who is waiting for the clarification of this function. I still don't know how to configure it correctly in order to correctly make a color selection. And imagine you paint your skin tone and how it affects your assessment. It's time to fix this and there should be nothing that restricts your work. We are waiting waiting waiting

[christians66072318]

jep i face this Problem daily. We shoot 10Bit h264 for Chromakey.
Impossible to pick the Color of the Green screen....what a "kindergarden".
I choose..no i guess the color myself out of the palette what take much longer then it should be ..if it its working as it should be..

[tomatosoup75]

My eyedropper has issues even with color management disabled, just saying.

[whisen82]

This just started with the latest version for me with the Change to Color effect which is now under obsolete? I use that effect like it's a religion.

[Lon Goldstein]

Thank you! This solution worked for me to make the color picker in the essential graphics panel select the correct color. I am first noticing this problem in Premiere v22.0, build 128. It was picking a color near by not exactly the color chosen. When I sampled the color from a still of the frame using Photoshop, and copied the hex code, and pasted it into the color picker, it was still off.

"Currently, the only way to properly sample any color is to turn off color management first".

[Matthew Aufiero]

My eyedropper has issues even with color management disabled, just saying. +1

Moderator note: Edited for content. Please do not use all caps when creating a reply.