Only certain Intel CPUs support QuickSync - and those must have an integrated Intel GPU present and enabled in order to even enable QuickSync at all. If you have an Intel CPU that absolutely requires a discrete GPU just to even run at all (for example, an F-series CPU or an X-series CPU), or if you have an AMD CPU, then you cannot have QuickSync at all. In fact, you cannot have hardware H.264 or HEVC encoding or decoding at all if you have an AMD APU with its integrated Radeon Vega graphics as its only available GPU because these low-end GPUs do not have a hardware encoder or decoder at all.
With that said, I do not recommend enabling QuickSync if you have an AMD GPU because both the integrated Intel UHD Graphics and the discrete Radeon GPU support OpenCL for renders (not to be confused with encodes), and enabling QuickSync would force Premiere Pro's hardware renderer to heavily favor the weaker GPU (in this case, the Intel one) for MPE GPU acceleration - in other words, the Intel GPU would show far higher usage than the discrete AMD one (on the order of something like 95% to 5%). Things are different with Nvidia GPUs because Adobe uses CUDA for Nvidia GPUs, and the only way to force the Intel GPU to use MPE GPU acceleration for effects rendering would be to switch the renderer to OpenCL mode (the default is CUDA).
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