This is the most frustrating issue I've ever had with Adobe Premiere and After Effects and I still cant seem to find a solution. Everytime I click anything outside of preimere or after effects (to drag a clip from finder for example) I would go back into Premiere or after effects and the play button wont work. I've tried everything I can and it still persists on both softwares. This bug has rendered my Adobe subscription futile as I can no longer work.
If that doesn't work, try resetting the Workspaces: Reset a workspace Reset the current workspace to return to its original, saved layout of panels. 1. Do one of the following: • Click the Workspace menu icon and select Reset to Saved Layout. • Choose Window > Workspace > Reset to Saved Layout. from here: https://helpx.adobe.com/premiere-pro/using/workspaces.html
If that doesn't work, try Preferences > Audio Hardware and set Input to None.
If that doesn’t work, try updating or rolling back your graphics driver directly from the video card manufacturer’s site. If NVIDIA, do a clean install of the latest Studio Driver (NOT the Game Driver)
If that doesn't work, try creating a new project and import the old one into it.