Both systems suffer from Kernel 41 crashes from time to time.
One system (AMD) that was running 'Software Only' within Premiere was problem free for a long time until I re-enabled 'CUDA' within Premiere Pro. The next day the entire system crashed when Premiere Pro was opening a project.
The other system (Intel i9) has had CUDA enabled for a long time and suffers from Kerenel 41 crashes probably once a week on average - depending on usage.
Adobe support remoted into the system - witnessed the PC crashing (kernel 41) after batch encoding AVC 10bit down to H264. After PC restarted and support resumed (talk about re-installing the GPU driver) which has been done numerous times with Nvidia support - I was told that I'm encoding too much in ME... Even though the issue happened when Premiere was opening a project (Crash) - generic editing (Crash) - Encoding ME (Crash).
No amount of encoding should cause a PC to shut down from a Kernel 41. Fair enough - the app itself crashing from time to time, but not the entire PC system. This issue is plauging two PC systems.