Ctrl+E is "Edit Original" which opens the file you have selected in whichever app is default for that file type in your OS. Chances are the update is confusing the pathing of this command. You might want to try importing this entire project into a new project and see if that clears up the links.
I've noticed if you try to Ctrl+E (or CMD+E in my case on macOS) one of the default, sample, included videos with Premiere, you get a similar error message pointing to the desktop of someone named Jennifer. Probably whoever originally created these clips for Adobe.