If that doesn't work, try resetting the Workspaces: Reset a workspace Reset the current workspace to return to its original, saved layout of panels. 1. Do one of the following: • Click the Workspace menu icon and select Reset to Saved Layout. • Choose Window > Workspace > Reset to Saved Layout. from here: https://helpx.adobe.com/premiere-pro/using/workspaces.html
If that doesn't work, try Preferences > Audio Hardware and set Input to None.
If that doesn’t work, try updating or rolling back your graphics driver directly from the video card manufacturer’s site.
If that doesn't work, try creating a new project and import the old one into it.
What type/s of media files are you working with? How many drives are you using, and what is the type and connection of each? What do you use each drive for? Premiere really seems to need either multiple internal SSDs for cache, projects, and media files ... or a very fast RAID array with a high-speed connection to the computer.