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I have an Imac with big Sur, and I try to open Premiere but it stays in the start screen, as if it was loading, but it doesn't finish starting.
What are the hard drives (how many, what kind, what is on each, what capacity, and how full)?
Remove the AEXD plugin. Then things should work OK again.
Sorry about that. We have an article that shows some suggestions. Check here: https://community.adobe.com/t5/premiere-pro/faq-how-to-troubleshoot-premiere-pro-crash-at-launch/td-...
Let us know how it goes.