Are you getting any error messages?
What's exactly happening?
Once I open a project file -
It will get start loading for few seconds and it will get freeze.
If I try to play on time-line it will get an error as - Premiere pro is not responding
Have you tried resetting Premiere preferences?
have you tried launching an autosave version? Have you done any updates recently? If so, revert to the premiere version that worked...