Although the breadcrumbs generate, if you select one of them, the topic relating to that breadcrumb does not display. You remain in the original topic. Secondly, if you do a search and select a topic from the Search results, the breadcrumbs do not change to reflect the location of the topic you selected in the Search results.
Try the RoboHelp Tour Introduction (grainge.org) and see if that works as expected. It's a different skin but I just generated the same project using an Indigo skin and it is working in the same way as on my site.
Try generating to a new location and if that fails create a new copy of the skin with a slightly different name and try that.
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