If you mean producing 3D models based on these designs, these can indeed be produced using the Substance 3D tools.
Substance 3D Designer may indeed be used to model chess pieces by producing greyscale images which will be used to model the chess pieces using displacement. This project by Clark Coots shows just that.
As you are getting started, I highly recommend checking out our Start 3D series, which is linked in the Resources section of this page under the Guides category. When you are done with the series, check out our First steps with Designer tutorial to jump into this powerful tool!
Let me know if you need anything else in your journey of discovery!
Luca Giarrizzo | QA Analyst, 3D & Immersive | Adobe