I have two versions of substance installed because I inherited a project from someone else so I unfortunately have to use the new version with the crappy icon.
Anyhow, on the older 2020.1.3 version I could import an image that's part of an image sequence (imagine 7gb of set pictures).
On the new version (downloaded yesterday) Substance just hangs. It's a pain in the butt. The way to temporarily fix it is moving my image in a folder on it's own. I don't know if it thinks it's loading UDIMs but I don't even have the option to toggle it off.