I have now been though every performance improvement recommended, reinsstalled LrC10.1 and an earlier GeForce driver, turned off syncing, and yet there is no improvement. LrC will load after about 15 seconds whereas in v10 it was near instant. In Library module, clicking on a thumbnail, the spinning wheel will appear for about 15-20 seconds and the screen will freeze. Once that clears, clicking through a series of 5 or 6 thumbnails, the wheel appears again for about 10 seconds, freezing the screen. Clicking on the LrC interface whilst the wheel is spinning, the monitor white-outs (see image) until the background activity has ended. During the freeze, the CPU runs at around 50% and the fan ramps up. During normal LrC operation, the CPU runs at around 4%. This has only become an issue since updating to 10.1. Is no-one else experiencing this?  
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