I know it's maddeninly unhelpful, but I have this problem as well. It happens most often when I'm working on a file that's 50MB or more, and most of the work I do in Photoshop CS5 easily swells past 100MB (large illustrations will do that to ya before you flatten them). I started noticing it after reformatting my hard drive this December, which had originally been partitioned into a Boot section and a User Data section. My scratch disk settings use my external hard drive as the primary and my internal hard drive as the secondary. I am running 10.6.8, Snow Leopard, no Suitcase or Fusion or anything. Time Machine is inactive. I have 4GB of ram. Whenever the message pops up, my computer begins to run slower as well, and for the past few weeks Photoshop has needed to be force quit because it freezes when I quit out of the application. Does anyone think reinstalling the program would help? This is my second install of this disc onto this machine, but when I got it reformatted, I missed a few programs during the uninstall. Will that impact my ability to reinstall? To everyone in this thread, it's little comfort, but you aren't alone. Maybe Adobe will figure this out soon.
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