I did this by accident but have now duplicated it on another MacPro... I was having the crazy long opening time for Photoshop 2019 with one specifc file that took anywhere from 22-50 seconds with a cold open of PS2019. This was on a 2010 MP 5,1 12 core 64GB AMD Radeon 7950, cruical 1tb ssd running Mojave in APFS... I wanted to put in a 2TB SSD. Accidentally, the drive was HFS+ format. I cloned Mojave 10.14.6 over with CCC and booted from the 2TB SSD not even looking at the format. PS2019 cold open of the same file... 6.2 seconds!!!! Couldn't beleive it. So, I tried another SSD with a clean instal of Mojave 10.14.6 on an APFS container. PS2019 cold open with my file: 22-28 seconds. I have another MacPro 4,1 (hacked to 5,1) 8 core 64GB AMDRad7950 running 10.14.6, crucial 1TB ssd in APFS. PS2019 cold open with my file time: 22 sec... Made a new clone to a blank ssd formated in HFS+... Booted. PS2019 cold open with my file: 7 seconds! All around better performance opening and saving large 16-bit psds... Seems better with the GPU also in Liquify and Select & Mask. I haven't compared everything yet... I'm going to stick with HFS+ for now. I have been searching for forums on old 2010 hardware performance with APFS... Not too much info. I have a 2015 MBP i7 quad 16GB AMD RadeonR9-2GB + IrisPro1536. It opens PS 2019 with my file in 6.2 seconds in APFS... Same as the MP 5,1 in HFS+... PS 20.0.6
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