I have a label template that I have been using for over a year now with no issue...until yesterday.
I recently got a new PC and reinstalled InDesign CS6 onto it and it seemed to be working just fine, but when I tried to print some of those labels yesterday the entire template is shrunk down by 1/8th of an inch all the way around causing the labels to be offset from the edges with only the centermost labels being perfectly aligned. This particular template does not go all the way to the edges of the page to begin with (see template example) so it doesn't have anything to do with my inkjet printer not printing to the edges.
Margins are set to zero, printer settings haven't been touched (I even printed to a different printer with the same results), and I've tried printing a copy of the document from another PC (running an even older version of ID) and it printed perfectly. Both my old and new PC run Windows 10.