I realize the following problem with Lightroom V6.1.1 after migrating my MacBook Pro to Mac OS-X El Capitan:
MacBook Pro Retina is the Main Monitor and NEC MultiSync PA271W is the 2nd Monitor.
Both Monitors are calibrated using Xrite i1 Profiler and I verified that the correct ICC-Profiles are associated with the Monitors (Mac OS-X System Configuration space).
In the Library Module everything is fine, but when I switch to the Development Module, the image on the 2nd Monitor gets dull after some seconds. Stepping forward one image, the image on the 2nd Monitor brightens up and gets dull again after some seconds.