It may be part of WIN10 however, after days of frustration found the fix. It is some fonts that causing the issue. Either it can load two many fonts (I had about 2500) in the fonts directory or there are corrupted fonts (or Type 1 fonts PSF) in the fonts directory. I have deleted all the fonts in the Windows Fonts directory and added back only the default fonts, Illustrator CS6 font drop down start working. Then I copy back (install) all fonts I had from the backup, the font drop down stop working. Then I deleted about half of the fonts from the Windows fonts director, here you go... fonts drop down start working. I have repeatedly test to simulated issue and clearly see it's directly connected to Fonts. Finally, I have cleaned up lots of fonts that I do not needed from the Windows Fonts directory, and got the Illustrator to work like before. Try this and see yourself.
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