Hi I had this issue while I were trialing PS CC 2017~2018 and finally found the cause. The issue is caused by duplicated profiles of the same application name with different path in this wacom xml file: C:\Users\your_user_name\AppData\Roaming\WTablet\Wacom_Tablet.dat This issue only happens on this scenario: 1.You have one application installed and works well in Wacom Properties and setting specific functions for it. 2.The application have a big update and whatever the reason, it changed the install Path in PC, for example: From C:\Program Files\Adobe\Adobe Photoshop CC 2017\Photoshop.exe To C:\Program Files\Adobe\Adobe Photoshop CC 2018\Photoshop.exe 3.You found that in Wacom Properties the application's ICON gone, at this time , it still works(even you remove old app), but does not have the current ICON for the application, instead it use the ICON that 'All Other' has. 4.So you set it again, but it did not replace old ICON and not work at all on new ICON(profile), so you decided to delete the old ICON. Then you lost the control of the application forever in Wacom Properties on new updated application. This is a temporarily solution that user end can do(works till it changed the install path again or wacom fix it.) , just follow the steps: Before doing this, please close all applications at first. 1.Go to Services(win+r and run services.msc) and stop 'Wacom Professional Service' service. 2.Use Notepad++ or similar app to open the file(do not use notepad.exe comes with windows) 'C:\Users\your_user_name\AppData\Roaming\WTablet\Wacom_Tablet.dat' 3.You should then find this or similar thing, duplicated profiles of the same application name 'Photoshop' in the file: Maybe it should not be called duplicated because of they have different AppID number, but by unknown reason , Wacom driver only use first old PS CC 2017 profile, ignore the second PS CC 2018 profile. 4. Now the thing is simple, delete the 'New' profile, this is a XML file so just delete it from '[AppIDX]~[/AppIDX]', on my case, I have to delete AppID7 section, X is the number which wacom driver assign it to application. So all PC has different number, you have to find it yourself. 5.Edit the path to match the new PS CC 2018's in first section and save the file. If you want, you can just delete old first one, so no need to edit anything others. But in case something goes wrong, I suggest keeps AppID has it's order form 1~X. Since this is an user end modification, no one knows what actually wacom driver works. 6.Restart 'Wacom Professional Service' service , it should now works with new updated application. This issue is a Wacom driver issue so it will also happened on any similar scenario with other softwares, for example CLIP Studio Paint, which it changed install path at new 1.6.7 of internal language version. You can refer to this post: Cintiq Express keys don't work on CSP! - CLIP STUDIO ASK
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