Okay, none of the above works for me. The unwanted layers always reappear after flattening / merging / saving As, even when I hide them. Here's what worked: 1) HIDE the layers you want to KEEP. (The layers you want to delete remain visible). 2) Select Tools > Advanced Editing > Touch-up Text Tool. 3) Hit Ctrl-A to select all visible text objects. 4) Hit Delete. 5) Select Tools > Advanced Editing > Touch-up Object Tool. 6) Hit Ctrl-A to select all visible objects. 7) Hit Delete. 8) Now, you want to "merge away" the unwanted layers, which are now empty. In the Layers pane, Click the "Options" pull-down and select "Merge Layers...". 9) Hold down CONTROL and click all the UNWANTED (empty) layers. 10) Click "Add". 11) In the right-hand pane (target layer), select the first layer that you want to KEEP. This will basically merge that layer with all the empty ones, and in effect, delete the empty layers. 12) Hit OK, and you're done. When you save the file, the layers you want to preserve are preserved, and the file size is smaller, reflecting the "deleted" layers. This thread didn't help me even though the subject seems to be precisely what I needed, so I came up with this "brute force" method... Hopefully this helps someone else in the same predicament. If there is a more efficient way of doing it, let me know.
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