Setting up MBP 2016 with SSD

I just picked up a new Macbook Pro 15 inch (specs below), along with the MBP I have also purchased a 1TB Samsung T3 external SSD, and have two 1TB Seagate Back Up Plus HDDs.

I'm new with the whole setting up hard drives deal, so if anyone would like to give me some advice on how I should be formatting my system for using Premiere and After Effects, I would greatly appreciate it!!

My MBP Specs

      - APPLE SM0512L SSD internal drive

             Capacity: 500.28 GB

             TRIM Support: Yes

             Link Width: x4

             Link Speed: 8.0 GT/s

             Detachable Drive: No

             BSD Name: disk0

             Partition Map Type: GUID Partition Table

        Volumes:

               EFI:

                      Capacity: 314.6 MB     - BSD Name: disk0s1    - Content: EFI

               Untitled:

                      Capacity: 499.31 GB     - File System: Journaled HFS+     - BSD Name: disk0s2     - Mount Point: /      - Content: Apple_HFS

              Recovery HD:

                      Capacity: 650 MB     - File System: Journaled HFS+     - BSD Name: disk0s3     - Content: Apple_Boot    

      - Intel Core i7 processor

             Processor Speed: 2.7 GHz

             Number of Processors: 1

             Total Number of Cores: 4

             L2 Cache (per Core): 256 KB

             L3 Cache: 8 MB

             Memory: 16 GB

     - AMD Radeon Pro 455

             Type: GPU

             Bus: PCIe

             PCIe Lane Width: x8  

            VRAM (Total): 2048 MB

     - Intel HD Graphics 530

             Type: GPU

             Bus: Built-In  

             VRAM (Dynamic, Max): 1536 MB