I've "upgraded" to Windows 10 and now Acrobat XI Pro won't work?

uninstall it.

clean per Download Adobe Reader and Acrobat Cleaner Tool - Adobe Labs

re-install it using your serial number and the install files.

You can use the appropriate link below for your installation file(s)

Downloadable installation files available:

• Suites and Programs:  CC 2015 | CC 2014 | CC | CS6 | CS5.5 | CS5 | CS4, CS4 Web Standard | CS3
• Acrobat:  DC, XI, X | X Suite | 9,8 | 9 standard    | 8 standard
• Captivate:  9 | 8 | 7 | 6 | 5.5, 5 | 1
• Cold Fusion:  11, 10 | 9.0.2, 9.0.1, 9.0.0, 8.0.1, 8.0.0, 7.0, 6.1, 6.0, 5.0, 4.0
• Contribute:  CS5 | CS4, CS3 | 3,2
• FrameMaker:  12, 11, 10, 9, 8, 7.2
• Lightroom:  6.5 | 6| 5.7.1| 5 | 4 | 3
• Photoshop Elements:  14,13,12,11,10 | 9,8,7 win | 8 mac | 7 mac
• Premiere Elements:  14,13,12,11,10| 9, 8, 7 win | 8 mac | 7 mac

Download and installation help for Adobe links

Download and installation help for Prodesigntools links are listed on most linked pages.  They are critical; especially steps 1, 2 and 3.  If you click a link that does not have those steps listed, open a second window using the Lightroom 3 link to see those 'Important Instructions'.