Is it possible to catch mouse click events?

Hello, I am tasked with looking for several professional libraries needed for product development in my company.

One of our planned product's core features requires click event handling within a PDF file, or the ability the detect bookmark/hyperlink click events. I can't seem to find any help about this specific issue, does anyone know if it's possible? And if it is, can it be done with natively with C#? Does it require a complicated workaround or JS event handling?

Thanks,

DK