Im going to say no it is not possible. If you look at the source code for Adobe's main Activity class, "AndroidActivityWrapper", you will see in its "onCreate()" function definition, that it does a tiny amount of setup, and then runs a method called "afterOnCreate()" which instantiates an object called "AIRWindowSurfaceView". I am going to take a wild guess that that class is the AIR runtime that your AIR app runs in. Assuming that I am right and the "AIRWindowSurfaceView" is the container for the SWF part of your AIR app, then any AS3 code you have that would initialize an ANE would happen after "onCreate()" had already fired.
Link below to someone having decompiled the Android/AIR JAR file. Because it is decompiled, you will see a tad bit of wonkiness to it, but the overall structure of the source is there.
I imagine that the only way for you to have something occur in "onCreate()" is if you could have the original source files that make an Android/AIR app possible, add your code to it, create a new JAR file of it, and have Flash CS6/CC use that instead of the one Adobe created when it publishes your AIR app. This approach, assuming it is even possible, would also require the runtime to be embedded with the app since you technically modified part of it.
https://searchcode.com/codesearch/view/85539041/