Animate 2017 crashes in an especific frame or file

Today is been a week since I started to paint some animate files por a final animation. Some of this archives crash all the program when I fill the lines with the bucket tool and this files can't be opened again without crashing all the program and sometimes the system. I already tried ending the program with task manager and restarting the computer. I'm working with an HP, 8 RAM, 900GB of internal memory, windows 10 software. The files normally don't exceed more than 4 layers and 100 frames.