YouTube Destroys Quality, What Should I Do?

I have been working on this animation for hours at this and nothing is working. I've been trying repeatedly to do everything I can. I have it saved as a .mov file, which I then compressed to an .mp4 file, and when I check it, it's perfect. However, when I upload it to YouTube, it makes a couple of the frames blurry. Mostly the parts where it shows text, where it's either pixelated or low quality. It confuses me, because at some points, it's completely clear. 
Also, what's the recommendation for audio settings? I tried Raw 44 hz but it was hurting my ears so I tried something else. It made the volume quality better, but it doesn't sound as clear as the original source. I will provide screenshots or information if needed. I'm fairly new to this software so any kind of help is greatly appreciated.