500 Internal Server Error

I currently have 2 domains on my server. The first one is serving CF templates fine, but the 2nd  is throwing a 500 error whenever a cfm template is hit. This error is thrown regardless of the contents of the template. A completly blank cfm template throws the error, but serves fine when changed to an htm file. There is no Application tag on the part of the site that is being accessed.

The fact that only 1 domain is throwing a 500 on a blank template leads me to believe that there is a server misconfiguration somewhere. I have verified that the cf connection is in place as well as the tomcat ISAPI for the domain in question. I believe a problem there would throw a 400 or 403 error however.

Does anyone have any ideas?

CF 10 64bit Running on IIS 7 Windows server 2008 R2 standard