503 errors after ~3 months w/ CF10

Server is not responding about every other day now. The service states that it's running. Restarting fixes it temporarily.

My first thought was that this was a client variables issue, since the 90 day purge causes people a lot of problems. But I've confirmed that the codebase doesn't reference "clientmanagement". I moved client variable storage to a database anyway (nothing is getting populated there), and turned global updates off. It still hangs after doing this.

There's not much in the logs (there are no hs*.log files, and no exceptions in the regular CF logs), and so far Fusion Reactor has not pointed to any smoking guns. About the only thing I can find is in the isapi_redirect.log file (ColdFusion10/config/wsconfig/1/):

[Wed Jul 23 18:44:05.215 2014] [13144:10964] [info] ajp_process_callback::jk_ajp_common.c (2066): current reuse count is 118 of max reuse connection 250 and total endpoint count 500

[Wed Jul 23 18:44:05.217 2014] [13144:6856] [info] ajp_process_callback::jk_ajp_common.c (2066): current reuse count is 119 of max reuse connection 250 and total endpoint count 500

[Wed Jul 23 19:48:52.294 2014] [13144:6344] [info] jk_open_socket::jk_connect.c (626): connect to 127.0.0.1:8012 failed (errno=61)

[Wed Jul 23 19:48:52.295 2014] [13144:6344] [info] ajp_connect_to_endpoint::jk_ajp_common.c (1047): Failed opening socket to (127.0.0.1:8012) (errno=61)

[Wed Jul 23 19:48:52.299 2014] [13144:6344] [error] ajp_send_request::jk_ajp_common.c (1669): (cfusion) connecting to backend failed. Tomcat is probably not started or is listening on the wrong port (errno=61)

[Wed Jul 23 19:48:52.301 2014] [13144:6344] [info] ajp_service::jk_ajp_common.c (2692): (cfusion) sending request to tomcat failed (recoverable), because of error during request sending (attempt=1)

[Wed Jul 23 19:48:53.402 2014] [13144:6344] [info] jk_open_socket::jk_connect.c (626): connect to 127.0.0.1:8012 failed (errno=61)

[Wed Jul 23 19:48:53.406 2014] [13144:6344] [info] ajp_connect_to_endpoint::jk_ajp_common.c (1047): Failed opening socket to (127.0.0.1:8012) (errno=61)

This leads me to believe the problem may be either with the IIS Connector, or with Tomcat itself, but I'm not sure where to go from here, if that's the case. We ran all the CF10 updates through update 12, and didn't initially redo the IIS Connector through wsconfig.exe, and restart IIS, but did about a month or so ago.

We also adjusted the JVM settings a bit:

-XX:MaxPermSize=192m --> 256m

and set the min and max JVM heap size to 2048 (from 1024). We have 6GB of RAM on the dedicated server.

Here's the JVM memory usage from the hour of the crash (green dots at the bottom indicate the server restart)

The ramp up without any garbage collection is the same thing we saw the last time the server crashed as well. I have the Fusion Analytics logs from the latest crash, if anybody would like to see a specific chart.

Any suggestions would be greatly appreciated. Thanks.