BKBK's code should work! If you created directory  c:\uploads\images\ and you still can not make it work my assumption is you have problem with permissions! Check with your hosting provider or if you have access to CF control panel permissions details,if you did not already you should grant some permissions (read, write, modify, read&execute, file listing, etc.) for that path( c:\uploads\images\).

What does your code look like? Something like this?

<cfif isDefined("form.image") >
    <cffile action = "upload"
        fileField = "image"
        destination = "c:\uploads\images"
        accept = "image/jpg,image/pjpeg,image/jpeg"
        nameConflict = "MakeUnique">
        Done uploading image!

<!--- Put the code to send email here including, for example, c:\uploads\images\#cffile.serverfile# as attachment --->
<cfelse>
    <cfform method="post" action="#cgi.script_name#"
        name="uploadForm" enctype="multipart/form-data">
        <cfinput name="image" type="file">
        <br><br>
        <cfinput name="submit" type="submit" value="Upload image">
    </cfform>
</cfif>